Sertraline
from Drugs & Therapy Perspectives
Differential features: Comparison of various features of selective serotonin re-uptake inhibitors (SSRIs) which have reportedly shown efficacy in patients with post-traumatic stress disorder (PTSD)[3,16,18]
FeatureSertralineFluoxetineFluvoxamineParoxetineUsual dosage (mg/day)50-20020-60100-30020-50Evidence of efficacy2 placebo-controlled trials in civilians2 placebo-controlled trialsUncontrolled studiesUncontrolled studiesPharmacokineticsHalf-life1 dayUp to 3 daysa1 day dayWash-out time required before MAOIs can be given2 weeks>/=5 weeks1 week2 weeksElderlyMinimally affected by ageMetabolised more slowlyMinimally affected by ageMetabolised more slowlyRelative potential for drug interactionsb++++++Relative incidence of adverse events: Nausea/vomitingc+++++ Drowsinessc++++++ Tremorc++++++ Sweating & impotence or
ejaculation failurec+++++ Treatment withdrawalc+++++Other specific adverse events Agitation, weight loss, dermatological reactions
a Its active metabolite norfluoxetine has a half-life of 7 to 15 days.b On the basis of in vitro data.c On the basis of prescription event monitoring data from the UK. MAOI = monoamine oxidase inhibitor; + to ++ lesser or greater incidence compared with other SSRIs.
Section 7 of 7
Drug Ther Perspect 17(16):1-5, 2001. © 2001 Adis International Limited
This is a part of article Sertraline Taken from "Sildenafil Soft Tab" Information Blog
No comments:
Post a Comment